Guidelines issued for use of antibody tests – Zweli Mkhize
Zweli Mkhize |
25 August 2020
Minister says having antibodies does however not mean you’re immune
Gauteng GP Collaboration- Engagement with Doctors and Health Professionals Notes from Minister Dr.Zwelini Mkhize’s Remarks
24 August 2020
The Moderator: Dr Dan Isreal My Fellow Panelists
Prof Salim AbdoolKarrim
Prof Guy Richards
Dr. David Jankelow
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My Fellow Colleagues in Health Care Members of the Media
Thank you very much for the invitation to address my fellow colleagues and troops who have taken up arms in one of the greatest wars of our area- the battle with the unseen enemy- Coronavirus.
In a strange way, the COVID-19 crisis a kind of battle that has activated us not only through pain and anxiety but has bound us together not only in the spirit of love, but it has also made us more humane, more caring and brought up a sense of solidarity where we support each other and show empathy.
Today is about you, the frontline health care worker. The ones in the trenches who hold the human face and render the human touch to all the policies, regulations, science and academic research that has flooded the health service delivery space as we were confronted with a virus for which we had no precedent and no formula. And so we had to learn as we traversed the path. No one had enough knowledge of this so we are all in this together as we navigate our pathway through unchartered territory
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After all is said and done, it is the doctor who must look and speak with the patients, who must make a decision and broker trust as he gives the diagnosis and recommends the treatment pathway. It is the doctor that must examine, test, probe, reassess, worry and dedicate his abilities towards the management of life. This is important for us because it’s the doctor must do this whilst having to grapple with his or her own uncertainties, rapidly evolving evidence, patient and community fear and anxiety and the added emotional burden of constantly worrying about one’s own safety as well.
We appreciate the uncertainly under which you are working and the frustrations you face due to fear of knowing every time that the next patient could be the one that infects you and not knowing how your own body will respond to the virus.
Tonight I am here to talk with all of you and hear your thoughts, fears, aspirations and innovations. I am here to celebrate the health professional and to salute you all for the sheer tenacity and resilience you have portrayed that has positioned us as leaders in the global COVID-19 response.
This battle has not been without its casualties- over 27 000 of our colleagues have become infected with the virus and tragically it has robbed us of 240 of our talented health care workers. We mourn every soul lost to this enemy. It is our duty to honour their sacrifice by committing fully to the safety and wellbeing of our health care workers. This is currently a critical issue of contemporary interest as I am sure you have all seen some of the labour un- rest in the media environment. For our part as government, no matter what happens, we will continue to endeavour to engage with structures representing health care workers as we seek to create a new culture of mutual understanding and respect.
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In the best interest of our patients, it is imperative that we find one another as government and labour engage and robustly on the issues that are causing concerns for health care workers.
I have recently had serious engagements with a number of trade unions and I have said if there is any health worker that raises matters of safety, it must be taken seriously. The only way of knowing that the matter is resolved is when structures representing government and labour jointly verify the situation health care worker safety and ensure satisfactory resolu- tions. We have adopted the slogan: NO PPE, NO WORK.
On a personal note, I must express my deep appreciation to all health workers who have really been the most able champions in this fight. Your passion, commitment, diligence and love for science has not only made my job as Minister of Health so rewarding, but it has truly been the highlight of my career to partner and learn from my esteemed colleagues in health care as I have observed South African expertise pushed to it’s absolute cutting edge.
When everybody asked us what keeps us going it is the sheer courage and dedication of our health care workers despite all the difficult circumstances
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Your messages of support, encouragement and optimism, even when we were in our dark- est ours of the surge, gave me energy to keep going everyday, with the full knowledge and comfort of your backing.
Now, as we experience a trough in our epidemic, let us not relent or fall into the trap of com- placence but rather ride the momentum so we can keep a flat curve and ensure our facilities, and yourselves, do not become overwhelmed.
We have now started to dismantle some of the field hospitals as we have concluded field hospital beds are no longer necessary and now we shift our focus to facility refurbishment and oxygen reticulation. We are also engaged in discussion to foster goo co-operation be- tween private and public sectors. This discussion needs to continue as we have learnt through this pandemic is that we are all health service providers and the future will be much better for all South Africans if we continue to operate as a united front.
Moreover, let us use this crisis to advance the cause of Universal Health Coverage through the National Health Insurance. As we are unified now against COVID-19, let us not allow a disintegration of this fraternal cohesion that has been forged between clinicians, scientists, academics and government. It has been this commitment to collaborating together, public and private sectors, that has ultimately given hope to our people.
At this point if I may give an update on where we are with the latest numbers:
Province
Total cases for 24 August 2020
Percentage total
Eastern Cape
85240
14,0
Free State
35367
5,7
Gauteng
206525
33,8
KwaZulu-Natal
110102
18,0
Limpopo
12643
2,1
Mpumalanga
23163
3,8
North West
24371
4,0
Northern Cape
9322
1,5
Western Cape
104667
17,2
Unknown
50
0,0
Total
611450
100,0
As of today, a cumulative total of 611 450 confirmed COVID-19 cases in South Africa have been recorded with 1 677 new cases identified.
Testing Data
The total number of tests conducted to date is 3 564 065 with 10 640 new tests conducted since the last report
Sector
Total tested
New tested
Private
2 013 886
57%
5 389
51%
Public
1 550 179
43%
5 251
49%
Total
3 564 065
10 640
Total Deaths and Recoveries
Regrettably, we report 100 more COVID-19 related deaths: 14 from KwaZulu-Natal, 36 in Mpumalanga, 12 from Gauteng, 8 from Limpopo, 11 from Eastern Cape and 19 from Western Cape. This brings the total number of COVID-19 related deaths to 13 159.
We extend our condolences to the loved ones of the departed and thank the health care workers that treated the deceased patients.
Province
Total Deaths
Total Recoveries
Eastern Cape
2800
80614
Free State
567
20678
Gauteng
3280
174248
KwaZulu-Natal
1962
92342
Limpopo
179
10661
Mpumalanga
296
21049
North West
224
17008
Northern Cape
106
6106
Western Cape
3745
93788
Total
13 159
516 494
Our recoveries now stand at 516 494, which translates to a recovery rate of 84%
Antibody Testing
Today I am pleased to announce that the Director General for Health has issued guidelines for the use of SARS CoV 2 antibody tests and that SAHPRA announced its approval of several test kits, both lab based and point of care or bedside rapid tests.
I am sure this is a very welcome development and I would like to especially thank the Minis- terial Advisory Committee on COVID-19 and the various members of the strategic manage- ment bodies in the department of health for all the hard work that has gone into ensuring that antibody tests are used appropriately and effectively as we continue to battle COVID-19
It will be important to understand the limitations of antibody testing. These include the following considerations:
Antibodies are usually detected more than 10 days after onset of symptoms or even only during convalescence (recovery).
A negative antibody test result does not reliably rule out prior SARS-CoV-2 infection. For instance, someone may not generate the antibodies or high enough titres for an- tibodies to be detected.
A positive antibody test result does not reliably prove prior SARS-CoV-2 infection. There is known cross-reactivity with other viruses and there may be antibodies al- ready existing in someone’s system that look like COVID-19 antibodies.
The detection of antibodies does not necessarily mean one is immune
For these and other reasons, the Department of Health has recommended the following use for antibody tests in the guidelines
Diagnosis of COVID-19-associated multi-system inflammatory syndrome in children (in these children the PCR test can produce false negative results)
To retrospectively diagnose COVID-19 individuals with occupational exposure to SARS-CoV-2 who have recovered from a COVID-19 compatible illness.
Use of SARS-CoV-2-specific IgG antibodies for epidemiological purposes, that is to identify and track the transmission of certain geographical areas or populations- this will be a particularly useful application that will complement our surveillance strate- gies.
Use of SARS-CoV-2-specific IgG, IgM and/or IgA antibodies as part of scientific studies and clinical trials