Detection and frequency of the C.1.2 mutated SARS-Cov-2 lineage in SA
30 August 2021
The Network for Genomics Surveillance in South Africa (NGS-SA, www.ngs-sa.org), which includes the National Institute for Communicable Diseases (NICD), KRISP at the University of KwaZulu-Natal (UKZN), University of Cape Town (UCT), Stellenbosch University (SUN), the University of the Free State (UFS), the University of Pretoria, the University of the Witwatersrand (WITS) and the National Health Laboratory Service (NHLS), has been monitoring changes in SARS-CoV-2, the virus which causes COVID-19, since March 2020.
C.1.2 Lineage
In May 2021, we detected a mutated group of related SARS-CoV-2 viruses in South Africa which we called the C1.2 lineage. C.1.2 has been detected in all provinces in South Africa at relatively low frequency (up to ~2% of genomes) from May to August 2021. This lineage possesses mutations within the genome that have been seen in other SARS-CoV-2 variants of interest (VOI) or variants of concern (VOC) but also other mutations which are novel.
The World Health Organization and the South African National Department of Health were alerted in July to circulation of this lineage. Lastly the NGS-SA is continuing to monitor the frequency of this lineage and tests to assess the functional impacts of these mutations are underway. Thus far the virus has not fulfilled the WHO criteria for VOC or VOI.